Aug
3
Different Outcomes On The Same Diet: The Path To Obesity Becomes Clearer
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Why is it that two people can consume the same high fat, high-calorie Western diet and one becomes obese and prone to diabetes while the other maintains a slim frame? This question has long baffled scientists, but a study by Yale School of Medicine researchers provides a simple explanation: weight is set before birth in the developing brain…
Jul
14
Anti-Obesity And Diabetes Drug Avoids Brain Effects That Troubled Predecessors
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A second-generation experimental anti-obesity and diabetes drug has shown promise in reducing body weight in rodents just as effectively as the predecessor rimonabant while avoiding the risk of psychiatric side effects that led to the withdrawal of rimonabant from the market and stopped further development of other brain-penetrating drugs of its type…
Mar
29
Compulsive Eating That Leads To Obesity Has Similar Biology To Drug Addiction
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US researchers working with rats have shown for the first time that the compulsion to overeat that leads to obesity has the same biological mechanism as seen in addiction to drugs like cocaine and heroin abuse: it affects the brain’s pleasure circuitry in a similar way…
Jan
27
Leptin-Based Pill To Control Hunger In Development At Universite De Montreal
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A Université de Montréal research team is developing a pill composed of leptin, the protein that tells our brain to stop eating. “Mice deprived of leptin will not stop eating. They become so big they have trouble moving around,” says Moïse Bendayan, a pathology professor at the Université de Montréal Faculty of Medicine who has studied the leptin protein extensively…
Nov
11
Dieters Can Experience Neurobiological Similarities Of Drug Addicts And Alcoholics
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Researchers from Boston University School of Medicine (BUSM) have shown that intermittent access to foods rich in fat and sugar induces changes in the brain which are comparable to those observed in drug dependence. The findings, reported in the journal Proceedings of the National Academy of Sciences, may explain how abstinence from these foods contributes to relapse eating among dieters as well as related eating disorders.
Oct
17
Our body’s activity levels fall and rise to the beat of our internal drums - the 24-hour cycles that govern fundamental physiological functions, from sleeping and feeding patterns to the energy available to our cells. Whereas the master clock in the brain is set by light, the pacemakers in peripheral organs are set by food availability. The underlying molecular mechanism was unknown.
Sep
15
Ice Cream May Target The Brain Before Your Hips, UT Southwestern Study Suggests
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Blame your brain for sabotaging your efforts to get back on track after splurging on an extra scoop of ice cream or that second burger during Friday night’s football game. Findings from a new UT Southwestern Medical Center study suggest that fat from certain foods we eat makes its way to the brain.
Sep
5
Leptin-Serotonin Pathway Offers New Clues For Obesity And Osteoporosis Prevention
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New research from Columbia University Medical Center has illuminated a previously unknown leptin-serotonin pathway in the brain that simultaneously promotes appetite and bone mass accrual. The research, which explains how leptin - well-known appetite-suppressing hormone - acts in the brain, is published in the Sept. 4 issue of Cell.
Sep
3
Exercise Minimizes Weight Regain By Reducing Appetite, Burning Fat,And Lowering ‘Defended’ Body Weight
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Exercise helps prevent weight regain after dieting by reducing appetite and by burning fat before burning carbohydrates, according to a new study with rats. Burning fat first and storing carbohydrates for use later in the day slows weight regain and may minimize overeating by signaling a feeling of fullness to the brain.
Sep
2
Animal Study Reveals How Exercise Minimizes Weight Regain
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Researchers in the US showed that exercise minimized weight regain in rats that lost weight on a long term diet and were then allowed to eat freely. The evidence suggests that exercise causes the body to burn fat first and store carbohydrates for later, a process that reduces appetite and signals fullness to the brain, leading to slower weight regain.